Eva is 6 ½ years old. She has been
battling rhabdomyosarcoma (soft tissue cancer) since she was 4 years old. She has endured numerous treatments and
amputation of her left arm and shoulder.
Despite everything she continues to go to school regularly, plays hockey
for a champion team, and does almost everything a child her age should be
doing. However, despite coping extremely
well with every treatment and procedure thrown her way, some tumours have disappeared and somecontinue
to grow. A recent genetic profiling
report indicated she has loss of the CDKN2A/B gene. This report indicates that tumours that show
loss of the CDKN2A/B gene are sensitive to CDK4/6 inhibitors. Eva has exhausted all treatment options
within the realm of paediatric cancer world.
A CDK4/6 inhibitor called PALBOCICLIB produced by PFIZER is currently in
extensive adult trials as this is a billion dollar drug. There are no trials for its use in children.
Pfizer have refused Eva’s
oncologist’s request for this drug. With
no treatment Eva will die.
Eva’s family are hoping that PFIZER will reconsider making PALBOCICLIB
available as it appears their only hope at this point. Eva needs a miracle!
Eva has nothing to lose and everything to gain by receiving this drug. If the treatment proves to be successful with few side effects, it can be used to save the lives of other people with similar issues.